Genetic predisposition affects weight gain with antipsychotic use
Epidemiology

Last Updated: 2002-06-17 13:19:55 -0400 (Reuters Health)
NEW YORK (Reuters Health) - Researchers have identified a polymorphism of the 5-hydroxytryptamine 2C (5-HT2C) receptor that is associated with weight gain related to the use of antipsychotic drugs. The finding appears in the June 15th issue of The Lancet.

Dr. Gavin P. Reynolds from the University of Sheffield, UK, and colleagues in Nanjing, China, studied 123 Chinese patients treated for a first episode of schizophrenia. The patients were weighed on admission to the hospital and each week thereafter. The patients received conventional antipsychotic drug therapy and a standard hospital diet.

The researchers genotyped the patients for the -759C/T polymorphism in the promotor region of the 5-HT2C receptor gene. They found that 18% of malepatients and 26% of female patients carried the -759T variant, and these patients had significantly less weight gain than those with the wild-type gene (p=0.0003).

Full text
http://www.reutershealth.com/archive/2002/06/17/professional/links/20020617epid003.html